4-Methyl Acetophenone: Applications, Properties, and Safety

4-Methyl Acetophenone, also known as p-Tolyl methyl ketone, is a chemical compound with various uses in industrial and research settings. This compound is notable for its role as an intermediate in the synthesis of pharmaceuticals and other organic compounds. With a distinct aromatic odor, it is often utilized in the fragrance industry as well.

The structure of 4-Methyl Acetophenone includes a benzene ring substituted with a methyl group and a carbonyl group, making it a useful reagent in organic chemistry. Researchers appreciate its versatility and efficacy in developing new synthetic pathways.

While primarily of interest to chemists and industrial professionals, 4-Methyl Acetophenone also finds applications in the production of dyes, resins, and agrochemicals. Its broad utility and importance in various sectors underscore its significance in modern chemical processing.

Chemical Properties and Structure

4-Methyl Acetophenone, also known as p-methylacetophenone, is an organic compound with distinctive chemical properties. Its structure and stability are vital to its applications and behavior in different environments.

Molecular Formula and Weight

4-Methyl Acetophenone has the molecular formula C9H10O, featuring a single benzene ring attached to a methyl group and a ketone group.

• Molecular Weight: Approximately 134.18 g/mol
• Chemical Composition: 81.07% carbon, 7.55% hydrogen, and 11.92% oxygen

The precise arrangement of atoms gives it unique characteristics, contributing to its distinctive aromatic properties.

Physical State and Appearance

At room temperature, 4-Methyl Acetophenone is usually found as a clear, colorless to slightly yellow liquid.

• Boiling Point: Around 226°C (439°F)
• Melting Point: Approximately 3°C (37°F)

Its density is roughly 1.008 g/cm³, making it slightly lighter than water. It has a faint, pleasant odor and a moderate refractive index, indicating how it bends light.

Chemical Stability and Reactivity

4-Methyl Acetophenone is generally stable under normal conditions. It does not react with water but may undergo oxidation or reduction reactions depending on the circumstances.

• Reactivity with Acids/Bases: Resistant to weak acids and bases
• Combustibility: Flammable, with a flash point of around 85°C (185°F)

In the presence of strong oxidizing agents, it can form various compounds. Its stability is crucial for industrial applications where it is used as an intermediate.

Applications and Usage

4-Methyl Acetophenone holds value in various sectors, including pharmaceuticals, fragrances, and industrial synthesis. It plays roles ranging from being a precursor in drug production to an additive in perfumes and organic reactions.

Pharmaceutical Use

In pharmaceuticals, 4-Methyl Acetophenone serves as an intermediate. It is vital in synthesizing various active pharmaceutical ingredients (APIs). Its structure enables modifications, making it useful for developing medications.

Primarily, it aids in producing analgesics and anti-inflammatory drugs. Additionally, its ketone group allows for further chemical modifications, enhancing its versatility in medicinal chemistry.

Fragrance and Flavor Industry

4-Methyl Acetophenone is a key component in the fragrance and flavor industry. Its pleasant aroma makes it a desirable additive in perfumes and colognes. Due to its musky, sweet fragrance, it enhances the olfactory profile of many cosmetic products.

In flavoring, it is used to create complex scent profiles in food products, contributing to the sensory appeal.

Organic Synthesis

In organic synthesis, 4-Methyl Acetophenone is frequently utilized as a building block. It is involved in various chemical reactions, including Friedel-Crafts acylation.

This compound is crucial in forming complex molecules, aiding in the manufacturing of dyes, plasticizers, and other industrial materials. Its reactivity makes it a staple in synthetic chemistry labs.